| Character Name | Japanese Voice Actor/Actress | English Voice Actor/Actress |
| Spike Spiegal: | Kôichi Yamadera | David Lucas |
| Jet Black: | Unshô Ishizuka | John Billingslea |
| Faye Valentine: | Megumi Hayashibara | Wendee Lee |
| Edward: | Aoi Tada | Melissa Charles |
| Ein: | N/A | N/A |
| Vicious: | Norio Wakamoto | George C. Cole |
| Julia: | Gara Takashima | Melissa Williamson |